Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug sensitivity test against malignant gliomas].

O Nakamura1, M Matsutani, K Nomura

  • 1Dept. of Neurosurgery, Metropolitan Komagome Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|June 1, 1990
PubMed
Summary

This study evaluated three in vivo models for testing anticancer drug efficacy against brain tumors. Human glioma-bearing nude mice and chick embryo models showed promise for predicting drug effectiveness in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment of a hepatocyte cell line producing growth-promoting factors for liver-colonizing tumor cells.

Japanese journal of cancer research : Gann·1996
Same author

Activation of glutathione transferase P gene by lead requires glutathione transferase P enhancer I.

The Journal of biological chemistry·1996
Same author

A novel clonality assay for the mouse: application to hepatocellular carcinomas induced with diethylnitrosamine.

Molecular carcinogenesis·1996
Same author

[A successful palliative arterial switch operation with arch repair for tricuspid atresia with ventriculoarterial discordance, subaortic stenosis, coarctation, and aortic arch hypoplasia].

[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai·1995
Same author

[Changes in the serum level of vitamin B12 binding protein in gastrectomized patients: preliminary report].

Nihon Geka Gakkai zasshi·1995
Same author

[Effects of insulin on hepatic energy metabolism of tumor-bearing pats: preliminary report].

Nihon Geka Gakkai zasshi·1995

Area of Science:

  • Oncology
  • Pharmacology
  • Experimental Medicine

Context:

  • Malignant brain tumors, particularly gliomas, present significant therapeutic challenges due to tumor heterogeneity.
  • Accurate preclinical models are crucial for evaluating anticancer drug sensitivity and predicting clinical outcomes.
  • Existing models vary in their ability to mimic human tumor biology and predict drug response.

Purpose:

  • To evaluate and compare the utility of three distinct in vivo models for assessing anticancer drug sensitivity in malignant brain tumors.
  • To determine the predictive value of each model for direct anticancer drug effects, biological response modifiers, and patient-derived gliomas.
  • To identify the most suitable preclinical models for guiding chemotherapy selection in brain tumor treatment.

Summary:

Related Experiment Videos

  • Three in vivo models were assessed: human glioma-bearing nude mice, methylcholantrene-induced mouse glioma models, and human gliomas in chick embryo chorioallantoic membranes (CAM).
  • Human glioma-bearing nude mice demonstrated high utility for predicting direct anticancer drug effects, with ACNU and interferons tested.
  • The chick embryo CAM model showed high grafting success and results comparable to nude mice, proving useful for predicting drug effects on patient-derived gliomas.

Impact:

  • Human glioma-bearing nude mice are identified as highly predictive for direct anticancer drug effects.
  • Immunocompetent mouse models offer insights into biological response modifiers and immunological changes.
  • The chick embryo CAM model provides a viable, high-success-rate platform for drug sensitivity testing, especially for patient-derived gliomas.