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Updated: Jul 20, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
Published on: January 4, 2017
Otosclerosis: etiopathogenesis and histopathology
Sebahattin Cureoglu1, Patricia A Schachern, Alfio Ferlito
1Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
Abstract:
Otosclerosis is a disease of the bony labyrinth manifesting clinically as a progressive conductive hearing loss, a mixed-type hearing loss, or a sensorineural hearing loss. The age of onset of the hearing loss caused by otosclerosis is principally between 15 and 40 years. Although histopathological inner ear changes due to otosclerosis have been very well documented, the true etiopathogenesis of the disease has yet to be described despite intensive research. Both genetic and environmental factors have been implicated, however.
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