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Central corneal thickness in patients with Weill-Marchesani syndrome
Mohammad Reza Razeghinejad1, Homayoon Safavian
1Shiraz University of Medical Sciences, Department of Ophthalmology, Khalili Hospital, Shiraz, Iran. razeghinejad@yahoo.com
Purpose:
To investigate whether central corneal thickness (CCT) is affected in patients with Weill-Marchesani syndrome (WMS) and to focus on its clinical significance.
Design:
Case-control study.
Methods:
Complete ocular examination was performed in case and control groups, and then the lowest reading of ten pachymetry measurements of the central cornea was taken as CCT.
Results:
All participants, case and controls, were female and age matched (P = .7). The mean of central corneal thickness in twelve eyes of six patients with WMS was thicker (631.5 +/- 25.9 microns) than 40 eyes of 20 normal persons (535.8 +/- 25.9 microns) in the control group (P < .0001).
Conclusions:
Increased CCT seems to be a previously unrecognized aspect of WMS. This may lead to overestimation of intraocular pressure by applanation tonometers. Therefore, unusually thick CCT should be considered in interpreting the Goldmann tonometric reading in diagnosis and management of glaucoma in this rare syndrome.
