Early onset endophthalmitis caused by Aspergillus species following cataract surgery

David Callanan1, Ingrid U Scott, Timothy G Murray

  • 1Texas Retina Associates, Dallas, Texas, USA. dcallanan@texasretina.com

Abstract

Insights

Early onset Aspergillus endophthalmitis after cataract surgery is rare but serious. Poor visual outcomes and eye removal (enucleation) are common, necessitating prompt diagnosis and treatment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Post-cataract surgery endophthalmitis can lead to severe vision loss.
  • Fungal infections, particularly Aspergillus, are a rare but significant cause.

Purpose of the Study:

  • To describe cases of early onset Aspergillus endophthalmitis following cataract surgery.
  • To highlight the clinical course and outcomes.

Main Methods:

  • Retrospective review of medical records.
  • Analysis of cases treated between 1992 and 2005.

Main Results:

  • Five patients with Aspergillus endophthalmitis were identified.
  • Mean diagnosis time was 29 days post-surgery.
  • 60% of affected eyes required enucleation; final visual acuity was poor in remaining eyes.

Conclusions:

  • Aspergillus should be considered in early-onset endophthalmitis after cataract surgery.
  • Visual outcomes are generally poor, with a high rate of enucleation.

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...