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Published on: December 1, 2023
Early onset endophthalmitis caused by Aspergillus species following cataract surgery
David Callanan1, Ingrid U Scott, Timothy G Murray
1Texas Retina Associates, Dallas, Texas, USA. dcallanan@texasretina.com
Purpose:
To report a series of patients with early onset Aspergillus endophthalmitis following cataract surgery.
Design:
Retrospective consecutive case series.
Methods:
Medical records were reviewed of all cases of endophthalmitis caused by Aspergillus after cataract surgery treated at the authors' practices between 1992 and 2005.
Results:
Five patients were identified. Two patients were immunocompromised (one on oral corticosteroids and one on chemotherapy for lung cancer). The mean number of days between cataract surgery and diagnosis with endophthalmitis was 29 (range, 10 to 62 days). Three eyes (60%) were enucleated despite a variety of treatments. In addition to vitrectomy and injection of antifungal agents, the other two eyes underwent surgical debridement of a localized necrotic nidus. Final visual acuity was 20/30 in one eye and 20/200 in the remaining eye.
Conclusions:
Aspergillus should be considered in the differential diagnosis of early onset endophthalmitis following cataract surgery. Visual outcomes are generally poor and enucleation is common in these patients.
Insights
Early onset Aspergillus endophthalmitis after cataract surgery is rare but serious. Poor visual outcomes and eye removal (enucleation) are common, necessitating prompt diagnosis and treatment.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Post-cataract surgery endophthalmitis can lead to severe vision loss.
- Fungal infections, particularly Aspergillus, are a rare but significant cause.
Purpose of the Study:
- To describe cases of early onset Aspergillus endophthalmitis following cataract surgery.
- To highlight the clinical course and outcomes.
Main Methods:
- Retrospective review of medical records.
- Analysis of cases treated between 1992 and 2005.
Main Results:
- Five patients with Aspergillus endophthalmitis were identified.
- Mean diagnosis time was 29 days post-surgery.
- 60% of affected eyes required enucleation; final visual acuity was poor in remaining eyes.
Conclusions:
- Aspergillus should be considered in early-onset endophthalmitis after cataract surgery.
- Visual outcomes are generally poor, with a high rate of enucleation.
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