Chondrocyte genomics: implications for disease modification in osteoarthritis

Advances in genomic technologies have made genome-wide-association and gene-expression studies a reality. Despite technical and analytical challenges, the application of genomic technologies to osteoarthritis research will lead to a better understanding of the disease at the molecular level. Functional genomics will identify genes involved in the chondrocyte response to cartilage injury and cartilage repair, and will help clarify the role of chondrocytes in arthritis onset, progression and outcome. Systems biology will enable researchers to develop a full portrait of osteoarthritis, a complex and multifactorial disease that involves not only articular cartilage but also synovium, synovial fluid, subchondral bone and peripheral blood. Ultimately such an approach will result in novel diagnostic and therapeutic targets and better disease management.