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Related Experiment Videos

Human immunodeficiency virus-associated nephropathy.

Chun-Fu Lai1, Jenq-Wen Huang, Wei-Chou Lin

  • 1Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|August 29, 2006
PubMed
Summary
This summary is machine-generated.

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Human immunodeficiency virus-associated nephropathy (HIVAN) can lead to rapid kidney failure. This case highlights that even with successful viral suppression, HIVAN may progress to end-stage renal disease.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Virology

Background:

  • Human immunodeficiency virus-associated nephropathy (HIVAN) is a severe kidney disease common in HIV-infected individuals.
  • Limited data exists on HIVAN prevalence and progression in Asian populations.
  • Early detection and management are crucial for kidney health in HIV patients.

Observation:

  • A 54-year-old Taiwanese man with HIV presented with cytomegalovirus retinitis, renal insufficiency, and nephrotic-range proteinuria.
  • Despite 31 months of highly active antiretroviral therapy (HAART), his condition rapidly progressed to end-stage renal disease (ESRD).
  • Renal biopsy confirmed HIVAN, showing collapsing focal segmental glomerulosclerosis and tubulointerstitial nephritis.

Findings:

  • The patient required maintenance hemodialysis due to kidney failure.

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  • Histopathological findings were consistent with HIVAN.
  • Despite HAART and viral suppression, the patient experienced rapid disease progression.

    • Implications:

    • This case underscores the potential for rapid progression of HIVAN to ESRD, even with effective antiretroviral therapy.
    • It highlights the need for increased awareness and research on HIVAN in Asian populations.
    • Further strategies may be needed to prevent or manage advanced kidney disease in HIV-infected individuals.