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The gaussian network model: precise prediction of residue fluctuations and application to binding problems

Burak Erman1

  • 1Department of Chemical and Biological Engineering, Koç University, Sariyer, 34450 Istanbul, Turkey. berman@ku.edu.tr

Biophysical Journal
|August 29, 2006
PubMed
Summary

This study optimizes the Gaussian Network Model's force constants for precise protein dynamics. The refined model accurately predicts residue-specific fluctuations and ligand binding effects, outperforming the standard model in higher-order motions.

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