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Updated: Jul 20, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
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Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

If current inhibition: cellular basis and physiology.

M E Mangoni1, L Marger, J Nargeot

  • 1CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.

Advances in Cardiology
|August 29, 2006
PubMed
Summary

The hyperpolarization-activated current (I(f)) drives cardiac automaticity. Ivabradine selectively inhibits I(f) channels, reducing heart rate by targeting this key mechanism in pacemaker cells.

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