Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart rate slowing for myocardial dysfunction/heart failure.

Paul Mulder1, Christian Thuillez

  • 1INSERM U644, Faculté de Médecine et de Pharmacie, Rouen, France.

Advances in Cardiology
|August 29, 2006
PubMed
Summary

Reducing heart rate in heart failure patients using ivabradine improved cardiac function. This effect persisted after treatment withdrawal, suggesting intrinsic myocardial improvements from pure heart rate reduction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-heparanase shields against endothelial dysfunction in a rat model of warm pulmonary ischemia-reperfusion.

Respiratory research·2026
Same author

Neutrophil Gelatinase-Associated Lipocalin Drives Cardiac Remodeling in Rats With Chronic Kidney Disease.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension.

Comprehensive Physiology·2026
Same author

Post-Ex Vivo Lung Perfusion Hypothermic Storage Limits Inflammation and Endothelial Dysfunction.

Journal of cardiothoracic and vascular anesthesia·2025
Same author

Correction: Karoui et al. Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction. <i>Int. J. Environ. Res. Public Health</i> 2020, <i>17</i>, 5526.

International journal of environmental research and public health·2025
Same author

Dual ET<sub>A</sub>-ET<sub>B</sub> receptor antagonism improves metabolic syndrome-induced heart failure with preserved ejection fraction.

Fundamental & clinical pharmacology·2025

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heart failure prevalence is increasing, with elevated heart rate contributing to cardiac dysfunction.
  • The impact of isolated heart rate reduction on heart failure progression remains unclear.

Purpose of the Study:

  • To investigate the effects of pure heart rate reduction on cardiac function in a rat model of heart failure.
  • To determine if chronic heart rate reduction improves intrinsic myocardial function.

Main Methods:

  • Utilized a rat model of heart failure.
  • Administered ivabradine, an I(f) channel blocker, to reduce heart rate without altering blood pressure.
  • Evaluated cardiac function and myocardial tissue characteristics after chronic ivabradine treatment.

Main Results:

Related Experiment Videos

  • Ivabradine dose-dependently reduced heart rate, improving cardiac function.
  • Improved cardiac function persisted after ivabradine withdrawal, indicating enhanced intrinsic myocardial function.
  • Potential mechanisms include improved oxygen supply-demand ratio and reduced myocardial collagen accumulation.

Conclusions:

  • Pure, chronic heart rate reduction can be beneficial in managing heart failure.
  • Ivabradine's effects suggest a therapeutic potential for isolated heart rate lowering in heart failure.