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Hypertension: which aspects of hypertension should we impact on and how?

Alberto Zanchetti1, Bernard Waeber

  • 1Centro di Fisiologia Clinica e Ipertensione, Università di Milano, Istituto Auxologico Italiano, Ospedale Maggiore, Milan, Italy. alberto.zanchetti@unimi.it

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|August 29, 2006
PubMed

Insights

Lowering blood pressure in hypertensive patients prevents cardiovascular complications. A fixed combination of an angiotensin-converting enzyme inhibitor and a diuretic effectively lowers systolic pressure.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension management is crucial for preventing cardiovascular complications.
  • International guidelines recommend blood pressure below 140/90 mmHg, with lower targets for patients with diabetes or renal impairment.
  • Systolic blood pressure is a key indicator of cardiovascular risk and arterial stiffness.

Purpose of the Study:

  • To evaluate the antihypertensive efficacy of a fixed-dose combination therapy compared to monotherapy.
  • To assess the impact on systolic and diastolic blood pressure control.

Main Methods:

  • The STRATHE Study compared a fixed low-dose combination of perindopril (angiotensin-converting enzyme inhibitor) and indapamide (diuretic) against other therapeutic strategies.
  • Participants included hypertensive patients, with a focus on achieving target blood pressure values.

Main Results:

  • The fixed-dose combination demonstrated greater antihypertensive efficacy, particularly in reducing systolic pressure, compared to single-agent therapies.
  • This combination facilitated reaching target blood pressure levels more effectively.

Conclusions:

  • Fixed-dose antihypertensive combinations, such as perindopril/indapamide, are a validated and effective option for initiating treatment in hypertensive patients.
  • This approach offers improved systolic pressure control and overall cardiovascular risk reduction.

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