Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Pitstop-2 analog impairs viability of aggressive lung cancer cells by disrupting nuclear pore integrity.

Nanoscale advances·2025
Same author

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells.

Discover nano·2025
Same author

Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration.

Exploration (Beijing, China)·2024
Same author

Synergistic in vivo anticancer effects of 1,7-heptanediol and doxorubicin co-loadedliposomes in highly aggressive breast cancer.

Journal of controlled release : official journal of the Controlled Release Society·2024
Same author

Membrane potential dynamics of C5a-stimulated neutrophil granulocytes.

Pflugers Archiv : European journal of physiology·2024

Related Experiment Video

Updated: Jul 20, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

The nuclear barrier is structurally and functionally highly responsive to glucocorticoids.

Victor Shahin1

  • 1Department of Pharmacology, University of Cambridge, UK. vs297@cam.ac.uk

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|August 29, 2006
PubMed
Summary

Glucocorticoids, essential steroid hormones, dynamically alter nuclear pore complex structure and permeability. This regulation is vital for controlling nuclear transport and mediating hormone action in eukaryotic cells.

More Related Videos

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Related Experiment Videos

Last Updated: Jul 20, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nuclear pore complexes (NPCs) form a selective barrier controlling transport between the nucleus and cytosol in eukaryotes.
  • The integrity of this nuclear barrier is crucial for maintaining cellular function and preventing pathological conditions.
  • Changes in NPC structure and permeability can impact DNA accessibility and cellular responses.

Purpose of the Study:

  • To review the effects of glucocorticoids on nuclear pore complex structure and permeability.
  • To elucidate the physiological significance of glucocorticoid-induced alterations in the nuclear barrier.
  • To highlight the role of NPCs in mediating glucocorticoid hormone action.

Main Methods:

  • Literature review of studies investigating NPC structure and function.
  • Analysis of research on the interaction between glucocorticoids and nuclear transport.
  • Synthesis of evidence on the impact of steroid hormones on the nuclear barrier.

Main Results:

  • Nuclear pore complexes exhibit responsiveness to hydrophobic molecules like glucocorticoids.
  • Glucocorticoid binding influences the structure and permeability of the nuclear barrier.
  • These dynamic changes are essential for the physiological effects of glucocorticoids.

Conclusions:

  • Glucocorticoid-induced modulation of nuclear pore complexes is a key mechanism for regulating nuclear transport.
  • The nuclear barrier's adaptability to steroid hormones is physiologically essential for glucocorticoid signaling.
  • Understanding these interactions is crucial for both basic science and therapeutic applications.