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Fulminant hepatic failure caused by Salmonella paratyphi A infection

Fahmi Yousef Khan1, Ahmed A Kamha, Ibrahim Y Alomary

  • 1Department of Medicine, Hamad General Hospital, PO Box 3050, Doha, Qatar. fakhanqal@yahoo.co.uk

World Journal of Gastroenterology
|August 29, 2006
PubMed

Insights

Fulminant hepatic failure in a young adult was successfully treated following Salmonella paratyphi A infection. Prompt antibiotic therapy with ceftriaxone and dexamethasone led to patient recovery.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Critical Care Medicine

Background:

  • Salmonella paratyphi A infections can lead to severe complications.
  • Fulminant hepatic failure (FHF) is a rare but life-threatening condition.
  • Early diagnosis and intervention are crucial for managing FHF.

Observation:

  • A 29-year-old patient presented with fever, headache, vomiting, and altered mental status.
  • Clinical examination revealed deep jaundice and signs of acute illness.
  • Blood cultures confirmed Salmonella paratyphi A infection.

Findings:

  • The isolated Salmonella paratyphi A strain was sensitive to ceftriaxone and ciprofloxacin.
  • The patient received ceftriaxone and high-dose dexamethasone treatment.
  • Recovery was observed within two weeks of treatment initiation.

Implications:

  • This case highlights the potential for Salmonella paratyphi A to cause FHF.
  • Ceftriaxone combined with dexamethasone may be an effective treatment strategy.
  • Aggressive management in the intensive care unit (ICU) is vital for favorable outcomes.

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