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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
[Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus]
Yan-hang Gao1, Pu-jun Gao, Dan Wang
1Department of Gastroenterology, First Hospital, Jilin University, Changchun 130021, China.
Objective:
To further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.
Methods:
Using Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.
Results:
rHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.
Conclusions:
The binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.
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