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Eosinophilic globules in pigmented spindle cell nevus.
1Department of Pathology, Catholic University of Chile, School of Medicine, Santiago.
The American Journal of Dermatopathology
|June 1, 1990
Summary
Reed's pigmented spindle cell nevus can be mistaken for melanoma. Identifying Kamino's eosinophilic globules helps differentiate this nevus, suggesting it's a variant of Spitz's nevus.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Reed's pigmented spindle cell nevus is frequently misdiagnosed as malignant melanoma.
- Clinical and histopathologic features can aid diagnosis but are sometimes insufficient.
Purpose of the Study:
- To investigate the presence of Kamino's eosinophilic globules in pigmented spindle cell nevus.
- To evaluate the utility of eosinophilic globules in differentiating pigmented spindle cell nevus from malignant melanoma.
Main Methods:
- Analysis of 10 cases of pigmented spindle cell nevus.
- Utilized step sections for detailed histopathologic examination.
- Focused on identifying Kamino's eosinophilic globules.
Main Results:
- Eighty percent of the studied cases exhibited numerous eosinophilic globules.
- This finding supports the classification of pigmented spindle cell nevus as a variant of Spitz's nevus.
- Kamino's eosinophilic globules were identified as a significant diagnostic marker.
Conclusions:
- The presence of Kamino's eosinophilic globules is a key feature of pigmented spindle cell nevus.
- These globules aid in distinguishing pigmented spindle cell nevus from malignant melanoma.
- Pigmented spindle cell nevus is likely a variant of Spitz's nevus.