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The genetic basis of inherited primary nocturnal enuresis: A UAE study

Riad A Bayoumi1, Valsamma Eapen, Saeed Al-Yahyaee

  • 1College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. bayoumi@squ.edu.om

Journal of Psychosomatic Research
|August 30, 2006
PubMed

Insights

Genetic factors strongly influence primary nocturnal enuresis (PNE). This study investigated PNE genetics in UAE children but found no linkage to previously identified loci on chromosomes 12 and 13, suggesting genetic heterogeneity.

Area of Science:

  • Genetics
  • Pediatrics
  • Urology

Background:

  • Primary nocturnal enuresis (PNE) is involuntary urination in children aged 5+ without organic cause.
  • Strong genetic factors are implicated, with ~75% of cases showing a family history.
  • Understanding the genetic basis of PNE is crucial for effective management.

Purpose of the Study:

  • To investigate the genetic underpinnings of primary nocturnal enuresis (PNE) in children from the United Arab Emirates (UAE).
  • To examine potential linkage of PNE to specific chromosomal regions previously associated with the condition.

Main Methods:

  • Genotyping of chromosomes 12 and 13 was performed in family members of 10 children with PNE across four large families.
  • Linkage analysis was conducted using previously reported microsatellite markers on chromosomes 12 and 13.

Main Results:

  • No evidence of linkage was found between PNE and the targeted loci on chromosomes 12 and 13 in the studied UAE families.
  • The findings did not support the previously reported genetic associations in this specific population.

Conclusions:

  • The study indicates no linkage between PNE and the investigated loci on chromosomes 12 and 13 in UAE children.
  • This suggests significant genetic heterogeneity in primary nocturnal enuresis, necessitating further research into other genetic factors and populations.
Abstract

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