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Simian virus 40 in posttransplant lymphoproliferative disorders
Regis A Vilchez1, Monica Patricia Jauregui, Eric D Hsi
1Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Human Pathology
|August 30, 2006
Summary
Simian virus 40 (SV40) DNA was detected in a small fraction of posttransplant lymphoproliferative disorder (PTLD) cases. This oncogenic virus may be linked to a subset of PTLDs, particularly EBV-negative PTLD.
Area of Science:
- Virology
- Oncology
- Immunology
Background:
- Simian virus 40 (SV40) is an oncogenic DNA virus linked to human malignancies.
- SV40 infection is hypothesized to contribute to posttransplant lymphoproliferative disorders (PTLDs) in immunosuppressed individuals.
Purpose of the Study:
- To investigate the association between SV40 and PTLD.
- To determine if SV40 is present and expressed in PTLD tissues.
Main Methods:
- Polymerase chain reaction (PCR) was used to detect SV40 T-ag gene sequences in PTLD DNA specimens.
- Sequence analysis confirmed SV40 T-ag detection.
- Immunohistochemical staining assessed SV40 T-ag expression in tumor cells.
Main Results:
- Epstein-Barr virus (EBV) was detected in 82% of PTLD cases.
- SV40 T-ag DNA sequences were found in 13% of cases with amplifiable DNA.
- SV40 T-ag expression was observed in malignant cells of one case with detectable SV40 DNA.
Conclusions:
- SV40 may be associated with a small subset of PTLD cases.
- Further research is needed to clarify SV40's role, especially in EBV-negative PTLD.
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