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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis
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Printing your own inkjet microarrays.

Christopher G Lausted1, Charles B Warren, Leroy E Hood

  • 1Institute for Systems Biology, Seattle, Washington, USA.

Methods in Enzymology
|August 30, 2006
PubMed
Summary

Inkjet printing offers an economical method for creating custom DNA arrays in small batches. This technology enables rapid and cost-effective prototyping of DNA array assays for systems biology research.

Area of Science:

  • Molecular Biology
  • Biotechnology
  • Genomics

Background:

  • High-throughput DNA/RNA analysis relies heavily on DNA arrays.
  • Economical production of small batches of custom oligonucleotide arrays is challenging.
  • Existing methods for mass production are not suitable for specialized applications.

Purpose of the Study:

  • To present inkjet printing as a viable method for producing custom oligonucleotide arrays.
  • To highlight the cost-effectiveness and speed of inkjet array prototyping.
  • To demonstrate the utility of inkjet arrays in systems biology.

Main Methods:

  • Adaptation of inkjet printing technology for molecular biology applications.
  • Utilization of programmable oligonucleotide synthesizers.

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  • Construction of a benchtop inkjet arrayer (POSAM).

    • Main Results:

    • Inkjet printing enables economical production of small batches of custom DNA arrays.
    • The POSAM arrayer can be built in-house by skilled laboratories.
    • Inkjet arrays facilitate rapid and inexpensive prototyping of DNA array assays.

    Conclusions:

    • Inkjet printing is a practical and accessible technology for custom DNA array production.
    • This method supports the evolving needs of systems biology research.
    • It provides a flexible solution for prototyping and specialized DNA array applications.