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Updated: Jul 20, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Peptide nucleic acid microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids

Mark A Witschi1, Jonathan K Pokorski, Daniel H Appella

  • 1Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland, USA.

Methods in Enzymology
|August 30, 2006
PubMed

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...