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Related Experiment Videos

Homocysteine.

Bradley A Maron1, Joseph Loscalzo

  • 1Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Clinics in Laboratory Medicine
|August 30, 2006
PubMed
Summary
This summary is machine-generated.

High homocysteine levels are linked to vascular diseases like heart and stroke. Accurate lab testing is crucial for predicting risk, but universal guidelines for homocysteine measurement are still needed.

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Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Elevated homocysteine levels are recognized as a significant risk factor for various vascular diseases.
  • Hyperhomocysteinemia is specifically implicated in coronary artery disease, cerebrovascular disease, and peripheral arterial disease.
  • Accurate detection and quantification of homocysteine are essential for effective cardiovascular risk prediction.

Purpose of the Study:

  • To review the evolution of laboratory strategies for homocysteine detection and quantification.
  • To highlight the need for improved accuracy in risk prediction for vascular diseases.
  • To address the lack of universal guidelines for circulating homocysteine determination.

Main Methods:

  • Review of laboratory-based strategies for homocysteine measurement.

Related Experiment Videos

  • Analysis of technological advancements in homocysteine quantification over the past two decades.
  • Assessment of the current landscape of homocysteine determination guidelines.

    • Main Results:

    • Homocysteine is a validated risk factor for multiple vascular pathologies.
    • Laboratory detection and quantification methods have advanced significantly in precision.
    • Despite technological progress, universal guidelines for homocysteine measurement are absent.

    Conclusions:

    • Accurate measurement of homocysteine is vital for vascular disease risk assessment.
    • Continued development in analytical techniques enhances precision but does not resolve guideline discrepancies.
    • The absence of universal guidelines poses challenges for consistent clinical application and risk stratification.