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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

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Updated: Jul 20, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Allergic eosinophilic esophagitis: a primer for pathologists.

Donald A Antonioli1, Glenn T Furuta

  • 1Department of Pathology, Beth Israel Deaconess Medical Center and Children's Hospital, Boston, Massachusetts 02215-5491, USA. dantonio@bidmc.harvard.edu

Seminars in Diagnostic Pathology
|August 31, 2006
PubMed
Summary

Allergic eosinophilic esophagitis is a growing condition in children and adults. This review covers its clinical, endoscopic, and pathologic features to aid diagnosis.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Allergic eosinophilic esophagitis is an emerging clinical-pathologic disorder.
  • Increasing recognition in pediatric and adult populations.

Purpose of the Study:

  • To review current clinical, endoscopic, and pathologic features of allergic eosinophilic esophagitis.
  • To summarize diagnostic parameters for this condition.

Main Methods:

  • Literature review of recent studies.
  • Evaluation of clinical presentations.
  • Analysis of endoscopic findings.
  • Assessment of histopathologic criteria.

Main Results:

  • Detailed description of clinical symptoms.
  • Identification of characteristic endoscopic findings.
  • Outline of key pathologic features, including eosinophilic infiltration.
  • Summary of diagnostic criteria.

Conclusions:

  • Allergic eosinophilic esophagitis requires a multidisciplinary diagnostic approach.
  • Understanding its features is crucial for accurate diagnosis and management.