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Related Experiment Videos

Collagenous and lymphocytic colitis.

Audrey J Lazenby1

  • 1Department of Pathology, University of Alabama School of Medicine, Birmingham 35429, USA. alazenby@path.uab.edu

Seminars in Diagnostic Pathology
|August 31, 2006
PubMed
Summary
This summary is machine-generated.

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Collagenous colitis and lymphocytic colitis are inflammatory bowel disorders causing watery diarrhea. Newer treatments like budesonide and bismuth are effective for both conditions.

Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Collagenous colitis (CC) and lymphocytic colitis (LC) are distinct chronic intestinal inflammatory disorders.
  • CC affects middle-aged women, characterized by subepithelial collagen and lamina propria inflammation.
  • LC has a varied presentation, affecting middle-aged individuals with a balanced sex ratio.

Purpose of the Study:

  • To differentiate the clinical and pathological features of collagenous colitis and lymphocytic colitis.
  • To review diagnostic criteria and therapeutic options for these conditions.

Main Methods:

  • Histopathological examination of intestinal biopsies.
  • Clinical data review of patient demographics and disease presentation.
  • Analysis of treatment outcomes for available therapies.

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Main Results:

  • CC diagnosis requires recognizing both collagen band and colitis; misdiagnosis can occur by focusing solely on collagen.
  • LC is defined by increased intraepithelial lymphocytes (median 30/100 cells) and mild lamina propria inflammation.
  • Both CC and LC show positive response to budesonide and high-dose bismuth preparations.

Conclusions:

  • Accurate diagnosis of CC and LC relies on comprehensive histopathological assessment.
  • Budesonide and high-dose bismuth represent effective therapeutic strategies for both CC and LC.
  • LC may present as a single episode in many cases and is associated with drugs, celiac disease, and family history.