Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steady-state kinetic behaviour of functioning-dependent structures.

Michel Thellier1, Guillaume Legent, Patrick Amar

  • 1Laboratoire 'Assemblages moléculaires: modélisation et imagerie SIMS', Faculté des Sciences de l'Université de Rouen, Mont-Saint-Aignan Cedex, France. Michel.Thellier@univ-rouen.fr

The FEBS Journal
|August 31, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The chromosomal origin of replication as the basis for the spatio-temporal biology of bacteria.

Frontiers in microbiology·2026
Same author

<i>Staphylococcus epidermidis</i> DnaK alters biofilm formation and proteome in <i>Staphylococcus aureus</i> CIP 107093.

Frontiers in microbiology·2026
Same author

Personality Traits: "The Big Five" and "the Dark Triad".

Clinics in plastic surgery·2025
Same author

60 Years of Studies into the Initiation of Chromosome Replication in Bacteria.

Biomolecules·2025
Same author

Hypothesis: bacteria live on the edge of phase transitions with a cell cycle regulated by a water-clock.

Theory in biosciences = Theorie in den Biowissenschaften·2024
Same author

Hunting the Cell Cycle <i>Snark</i>.

Life (Basel, Switzerland)·2024
Same journal

PDC1 deficiency results in 2-deoxyglucose sensitivity through inhibition of Pdc2 activity in yeast.

The FEBS journal·2026
Same journal

Epigenetic regulation of the hepcidin gene expression in hepatoma cells.

The FEBS journal·2026
Same journal

Loss of Ambp ameliorates steatosis progression by activating PPARα signaling in zebrafish.

The FEBS journal·2026
Same journal

Varying susceptibility of subpopulations along the epithelial-mesenchymal spectrum to undergo EMT.

The FEBS journal·2026
Same journal

ALOX15 links lipid metabolism to receptor trafficking in platelet activation.

The FEBS journal·2026
Same journal

A two-component ortholog of the Niemann-Pick C 1 protein is essential for normal growth and sterol trafficking and signaling in Tetrahymena thermophila.

The FEBS journal·2026
See all related articles

Functioning-dependent structures (FDSs), protein assemblies that form and dissolve for tasks, can regulate metabolism and signaling. These structures exhibit complex kinetic properties, akin to electronic circuits, enabling system coordination.

Area of Science:

  • Biochemistry
  • Systems Biology
  • Biophysics

Background:

  • Metabolic and signaling pathways require coordination for cellular function.
  • The mechanisms underlying this coordination remain a fundamental biochemical problem.
  • Functioning-dependent structures (FDSs) are hypothesized to play a role in this coordination.

Purpose of the Study:

  • To investigate the potential role of functioning-dependent structures (FDSs) in coordinating metabolic and signaling pathways.
  • To analyze the kinetic properties of FDSs using a computational model.

Main Methods:

  • Numerical study of steady-state kinetics.
  • Modeling a system of two sequential monomeric enzymes (E(1) and E(2)) forming FDSs.

Main Results:

Related Experiment Videos

  • Functioning-dependent structures (FDSs) exhibit unique kinetic properties not observed in individual enzymes.
  • These properties include linearity, invariance, pulsing, and switching, mirroring characteristics of electronic circuits.
  • FDSs demonstrate the capacity to generate regulatory and coordinating kinetics.

Conclusions:

  • Functioning-dependent structures (FDSs) can generate kinetics capable of regulating and coordinating metabolism and signaling.
  • The assembly and disassembly dynamics of FDSs may be a characteristic feature of living systems, reflected in entropy production.
  • FDSs offer a novel perspective on cellular organization and function.