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Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
Published on: August 20, 2015
Human hair keratin-associated proteins (KAPs)
Michael A Rogers1, Lutz Langbein, Silke Praetzel-Wunder
1Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany.
International Review of Cytology
|August 31, 2006
Summary
This review details human hair keratin-associated proteins (KAPs), their genes, and expression. It explores KAP variations and their potential roles in hereditary hair diseases and abnormalities.
Area of Science:
- Molecular Biology
- Genetics
- Dermatology
Background:
- Significant progress in identifying human hair follicle structural proteins, particularly keratins and keratin-associated proteins (KAPs), has been made.
- Research over the past decade has built upon decades of prior work in other species.
- Understanding KAPs is crucial for comprehending hair follicle structure and function.
Purpose of the Study:
- To review and describe the known human KAP families, their genomic organization, and expression patterns.
- To explore polymorphic variations within human KAP genes.
- To investigate the potential involvement of KAP proteins in hereditary hair diseases and hair abnormalities observed in transgenic models.
Main Methods:
- Literature review and synthesis of existing research on human hair follicle structural proteins.
- Analysis of genomic organization and expression characteristics of KAP families.
- Examination of studies on KAP gene polymorphisms and their association with hair phenotypes, including transgenic mouse models.
Main Results:
- Comprehensive overview of human KAP families, their genetic makeup, and how they are expressed.
- Identification of polymorphic variations in human KAP genes.
- Evidence suggesting a role for KAPs in hereditary hair disorders and hair abnormalities.
Conclusions:
- Human KAP genes and proteins are key structural components of the hair follicle.
- Variations in KAP genes may contribute to hereditary hair diseases.
- Further research into KAPs offers potential insights into hair development and pathology.
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