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Published on: July 20, 2014
[Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma]
Zheng-xiao Li1, Zhen-hui Peng, Fan-pu Ji
1Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Objective:
To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).
Methods:
Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.
Result:
Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.
Conclusion:
Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.
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