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Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
Isabel García1, Sofía Ballesta, Concepción Murillo
1Department of Microbiology, School of Medicine, University of Seville, Seville-41009, Spain. igarcial@us.es
Abstract:
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.
