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Related Experiment Videos

Paroxetine useful for palmar-plantar hyperhidrosis.

Samir Kumar Praharaj1, Manu Arora

  • 1Central Institute of Psychiatry, Ranchi, Jharkhand, India. samirpsyche@yahoo.co.in

The Annals of Pharmacotherapy
|August 31, 2006
PubMed
Summary
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Paroxetine effectively reduced excessive sweating in a patient with palmar-plantar hyperhidrosis (PPH). This treatment improved the patient's daily functioning and was well-tolerated over six months, suggesting paroxetine as a potential therapy for PPH.

Area of Science:

  • Clinical Case Study
  • Pharmacology
  • Dermatology

Background:

  • Palmar-plantar hyperhidrosis (PPH) is a condition characterized by excessive sweating of the palms and soles.
  • PPH can significantly impact a patient's socio-occupational functioning and quality of life.

Observation:

  • A case study involving a 32-year-old male diagnosed with PPH.
  • The patient experienced symptoms since childhood.
  • Treatment involved paroxetine, starting at 10 mg/day and increasing to 20 mg/day.

Findings:

  • Significant reduction in sweating of palms and soles was observed after one month of paroxetine treatment.
  • Marked improvement in socio-occupational functioning was reported.
  • Benefits were sustained at six-month follow-up with no emergent adverse effects.

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Implications:

  • Paroxetine's anticholinergic or antianxiety effects may contribute to its efficacy in treating PPH.
  • Paroxetine presents a potential therapeutic option for managing palmar-plantar hyperhidrosis.