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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Subtype of mild cognitive impairment and progression to dementia and death

Kristine Yaffe1, Ron C Petersen, Karla Lindquist

  • 1Department of Psychiatry, University of California, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu

Dementia and Geriatric Cognitive Disorders
|August 31, 2006
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) subtypes influence dementia risk and cause of death. Amnestic MCI is linked to Alzheimer's, while other subtypes may increase mortality risk.

Area of Science:

  • Neurology
  • Gerontology
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia.
  • Limited understanding exists regarding MCI heterogeneity and its impact on clinical outcomes.
  • This study investigates the longitudinal course and progression of MCI subtypes.

Purpose of the Study:

  • To determine the longitudinal course of different mild cognitive impairment (MCI) subtypes.
  • To assess the rate of progression from MCI to dementia and to death based on MCI subtype.
  • To analyze the influence of MCI subtypes on the type of dementia diagnosed.

Main Methods:

  • Longitudinal study of 327 patients with MCI (amnestic, single nonmemory, multiple domain).
  • Cox proportional hazard models used to assess time to dementia diagnosis and death.
  • Fisher's exact test employed to determine the type of dementia across MCI subtypes.

Main Results:

  • 65% of MCI patients progressed to dementia; 24% died within a mean follow-up of 3.1 years.
  • Non-amnestic MCI subtypes showed borderline significance for lower dementia risk but higher mortality risk compared to amnestic MCI.
  • Significant differences observed in dementia type diagnosis across MCI subtypes (p=0.006).

Conclusions:

  • Most patients with MCI progress to dementia, with a notable proportion experiencing mortality.
  • MCI subtype appears to influence progression rates to dementia and death.
  • MCI subtype significantly impacts the specific type of dementia diagnosed post-MCI.

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