Brevundimonas vesicularis septic arthritis in an immunocompetent child

Yael Sofer1, Samra Zmira, Jacob Amir

  • 1Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva 49202, Israel.

Insights

Septic arthritis can rapidly destroy joints. This case report details a toddler’s shoulder infection caused by Brevundimonas vesicularis, a rare pathogen, successfully treated with cefuroxime.

Area of Science:

  • Medical microbiology
  • Pediatric infectious diseases
  • Orthopedic surgery

Background:

  • Septic arthritis is a severe joint infection, often caused by common bacteria like Staphylococcus aureus.
  • Identifying the causative agent is crucial for effective treatment, especially in pediatric cases.
  • Brevundimonas vesicularis is an uncommon pathogen, rarely implicated in human infections.

Observation:

  • A previously healthy toddler presented with septic arthritis affecting the shoulder joint.
  • Cultures identified Brevundimonas vesicularis as the causative microorganism.
  • This represents the first reported human infection with B. vesicularis causing septic arthritis.

Findings:

  • Prompt administration of cefuroxime led to a complete recovery in the affected child.
  • The case highlights B. vesicularis as a potential pathogen in pediatric septic arthritis.
  • This is the first documented instance of B. vesicularis infection in an immunocompetent child.

Implications:

  • Clinicians should consider a broader range of microorganisms, including B. vesicularis, in pediatric septic arthritis cases.
  • Early diagnosis and appropriate antibiotic therapy are key to favorable outcomes.
  • This finding expands the known spectrum of B. vesicularis pathogenicity.

Related Concept Videos

Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...