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Related Experiment Videos

WWOX protein expression in normal human tissues.

Maria I Nunez1, John Ludes-Meyers, C Marcelo Aldaz

  • 1Department of Carcinogenesis, M.D. Anderson Cancer Center, Science Park-Research Division, The University of Texas, P.O. Box 389, Smithville, TX 78957, USA.

Journal of Molecular Histology
|August 31, 2006
PubMed
Summary
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The WW domain-containing oxidoreductase (WWOX) protein is highly expressed in secretory epithelial cells of reproductive, endocrine, and exocrine organs, and in neural cells. Its expression is absent in connective and adipose tissues.

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • The WW domain-containing oxidoreductase (WWOX) gene is a tumor suppressor located at a common fragile site.
  • Previous research primarily focused on WWOX RNA expression in cancer.
  • Normal WWOX protein expression patterns in non-neoplastic tissues remain largely uncharacterized.

Purpose of the Study:

  • To comprehensively analyze the normal tissue expression pattern of WWOX protein.
  • To investigate the topographic distribution of WWOX protein across various human organs.
  • To correlate WWOX expression with potential physiological functions, particularly in sex-steroid metabolism.

Main Methods:

  • Immunohistochemistry using a specific anti-WWOX polyclonal antibody.
  • Analysis of tissue cores from over 30 human organs using tissue microarrays (TMA).

Related Experiment Videos

  • Examination of whole tissue sections from hormonally regulated organs (breast, ovaries, testes, prostate).

    • Main Results:

    • WWOX protein is highly expressed in secretory epithelial cells of reproductive, endocrine, and exocrine organs.
    • Significant WWOX expression was observed in ductal epithelial cells of the urinary system and in neural cells (neurons, ependymal cells, astrocytes).
    • WWOX expression was notably absent in adipose, connective, lymphoid tissues, myelinized structures, and blood vessels.

    Conclusions:

    • The study defines the normal tissue distribution of WWOX protein.
    • Findings suggest a potential physiological role for WWOX in secretory and neural tissues.
    • This detailed expression map provides a foundation for understanding WWOX's function and its role in disease.