Nano-dispensing by electrospray for biotechnology

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Updated: Jul 20, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Maxim E Kuil1, Jan Pieter Abrahams, Jan C M Marijnissen

  • 1Biophysical Structure Chemistry, Leiden Institute for Chemistry, Leiden, The Netherlands. m.kuil@chem.leidenuniv.nl

Biotechnology Journal
|August 31, 2006
PubMed

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Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...