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[Effects of moxibustion preconditioning on SOD and MDA in rats with global brain ischemia]
Jin-shuang Hua1, Li-ping Li, Xian-min Zhu
1Henan College of TCM, Zhengzhou 450008, China. hjsh2002@126.com
Objective:
To reveal the mechanism of moxibustion preconditioning in preventive brain-protecting action.
Methods:
The rat model of global brain ischemia was made with 4-artery ligation method. 78 Wistar rats were randomly divided into 5 groups: normal control group, sham-operation group, brain ischemia group, brain ischemia preconditioning group and moxibustion preconditioning group. The brain was taken 24 h, 48 h and 72 h after operation in the all groups, respectively, for determination of SOD activities by xanthine oxidase method and MDA content by thibabituric acid method.
Results:
The SOD activity significantly increased, especially 24 h after the moxibustion preconditioning, and the MDA content decreased significantly with a very significant difference as compared with the ischemia group(P<0.01).
Conclusion:
Moxibustion preconditioning exerts the protective action on the brain tissue of ischemia and anoxia through increasing the endogenous anti-oxidase activity.
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