Popular sweetner sucralose as a migraine trigger
Related Experiment Video
Updated: Jul 20, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Rajendrakumar M Patel1, Rakesh Sarma, Edwin Grimsley
1Department of Internal Medicine, Mercer University School of Medicine, Macon, GA, USA.
Abstract:
Sucralose (trichlorogalactosucrose, or better known as Splenda) is an artificial sweetener from native sucrose that was approved by the FDA on April 1, 1998 (April Fool's Day). This observation of a potential causal relationship between sucralose and migraines may be important for physicians to remember this can be a possible trigger during dietary history taking. Identifying further triggers for migraine headaches, in this case sucralose, may help alleviate some of the cost burden (through expensive medical therapy or missed work opportunity) as well as provide relief to migraineurs.
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