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Updated: Jul 20, 2026
10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
An unexpected case of panuveitis
1Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK. manoj.malu@uhl-tr.nhs.uk
International Journal of STD & AIDS
|September 1, 2006
Summary
Atypical skin symptoms in secondary syphilis complicated by HIV co-infection delayed diagnosis, but intravenous benzyl penicillin treatment led to visual recovery.
Area of Science:
- Infectious Diseases
- Ophthalmology
- Dermatology
Background:
- Syphilis is a sexually transmitted infection caused by *Treponema pallidum*.
- HIV co-infection can alter the presentation of secondary syphilis.
- Ocular syphilis can lead to significant visual impairment.
Observation:
- A patient with HIV co-infection presented with unusual skin manifestations of secondary syphilis.
- The atypical rash led to a diagnostic delay.
- The patient experienced severe vision loss prior to diagnosis.
Findings:
- The patient was diagnosed with secondary syphilis and HIV co-infection.
- Treatment with intravenous benzyl penicillin was initiated.
- Despite initial severe visual loss, the patient showed a slow but positive response to treatment.
Implications:
- This case highlights the importance of considering syphilis in patients with atypical dermatological presentations, especially those with HIV.
- Early diagnosis and treatment are crucial to prevent irreversible visual damage.
- Intravenous benzyl penicillin remains an effective treatment for ocular syphilis, even in advanced stages.
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