Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Toxic epidermal necrolysis].

Anette Bygum1, Klaus Ejner Andersen

  • 1Odense Universitetshospital, Dermato-venerologisk Afdeling I, Odense C. anette.bygum@ouh.fyns-amt.dk

Ugeskrift for Laeger
|September 1, 2006
PubMed
Summary

Toxic epidermal necrolysis (TEN) is a severe drug reaction affecting skin and mucous membranes. Treatment emphasizes supportive care, as specific therapies lack evidence-based acceptance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Classification of angioedema types using decision tree modeling.

Frontiers in immunology·2026
Same author

Ugeskrift for laeger·2026
Same author

Garadacimab-gxii-A Novel Prophylactic Treatment for Hereditary Angioedema: A Drug Review.

The Annals of pharmacotherapy·2026
Same author

Unsuspected Adverse Drug Reactions to Dermatologic Medications: An Epidemiological Hypothesis-Free Screening Study of Real-World Data in Denmark.

Drug safety·2025
Same author

[Autoimmune progesterone dermatitis].

Ugeskrift for laeger·2025
Same author

Ugeskrift for laeger·2025

Area of Science:

  • Dermatology
  • Pharmacology
  • Intensive Care Medicine

Context:

  • Toxic epidermal necrolysis (TEN) is a rare but life-threatening mucocutaneous reaction.
  • It is predominantly drug-induced and characterized by widespread symptoms and organ involvement.
  • Current management relies on multidisciplinary supportive intensive care.

Purpose:

  • To discuss the clinical syndrome of TEN.
  • To outline diagnostic criteria for TEN.
  • To explore the pathogenesis and potential disease-limiting drug therapies for TEN.

Summary:

  • TEN presents as a severe mucocutaneous reaction, often drug-induced, with systemic and organ involvement.
  • Management is primarily supportive within an intensive care setting, requiring interdisciplinary collaboration.
  • Evidence-based specific treatments for TEN are still limited, necessitating further research.

Impact:

  • Highlights the critical need for improved diagnostic and therapeutic strategies for TEN.
  • Emphasizes the importance of multidisciplinary care in managing this severe condition.
  • Informs clinical practice and future research directions for drug-induced skin reactions.

Related Experiment Videos