Related Experiment Video

Updated: Jul 20, 2026

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

Substance P receptor mediated maintenance of chronic inflammation in EAE

Emily K Reinke1, Matthew J Johnson, Changying Ling

  • 1Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison WI, United States.

Journal of Neuroimmunology
|September 1, 2006
PubMed

Insights

Substance P (SP) and its receptor neurokinin-1 (NK-1) play a role in central nervous system inflammation. Blocking NK-1 may help treat neuroinflammatory diseases like multiple sclerosis.

Area of Science:

  • Neuroimmunology
  • Inflammation research

Background:

  • Substance P (SP) is a pro-inflammatory neuropeptide.
  • The SP receptor, neurokinin-1 (NK-1), is implicated in inflammatory processes.

Purpose of the Study:

  • To investigate the role of the NK-1 receptor in experimental autoimmune encephalomyelitis (EAE).
  • To evaluate the therapeutic potential of NK-1 antagonism in EAE.

Main Methods:

  • Utilized a mouse model of EAE.
  • Assessed the impact of NK-1 deficiency and NK-1 antagonist (SR140333) treatment on disease progression.
  • Quantified immune cell populations, including MOG-specific CD4+ T cells.

Main Results:

  • Mice lacking NK-1 showed improved mobility and reduced pro-inflammatory CD4+ T cells during the chronic phase of EAE.
  • Administration of SR140333 alone did not ameliorate EAE symptoms.
  • SP signaling via NK-1 contributes to the maintenance of central nervous system inflammation.

Conclusions:

  • Targeting the NK-1 receptor is a potential strategy for managing neuroinflammatory conditions.
  • Combining NK-1 antagonists with existing anti-inflammatory therapies may improve treatment outcomes for multiple sclerosis.

More Related Videos

Development of Recombinant Proteins to Treat Chronic Pain10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...