Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular cognitive impairment.

John T O'Brien1

  • 1Institute for Ageing and Health, Wolfson Research Centre, Newcastle-upon-Tyne, UK. j.t.o'brien@ncl.ac

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|September 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies.

Journal of biomedical science·2026
Same author

Midlife dementia risk and later dementia-related fear and avoidance: evidence from a prospective cohort study.

Aging & mental health·2026
Same author

Seven tesla MRI reveals amygdala and hippocampal subfield atrophy in dementia with Lewy bodies.

Alzheimer's research & therapy·2026
Same author

Repurposed drug prioritization pipeline for a multi-arm platform trial in clinical Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Genetic risk of Alzheimer's disease is associated with loss of brain network segregation in midlife.

Communications biology·2026
Same journal

Identifying Interpersonal Targets of Predeath Grief: A Reply to Tribhuvan and Phatke.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same journal

Postoperative Delirium as a Modifiable Determinant of Cognitive Decline After Hip Fracture Surgery: Implications for Geriatric Psychiatry.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same journal

Mediation in a Self-Guided Digital Intervention for Dementia Caregivers Worldwide: Insights and Challenges From the PDC30 Trial.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same journal

Reconsidering Outcome Metrics and Clinical Meaning in Late-Life Anxiety Treatment.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same journal

Response to "Comment on 'A Systematic Review and Meta-Analysis of Diagnostic Remission, Treatment Response, Attrition and Relapse Following Cognitive Behavior Therapy (CBT), Other Psychological Therapies and Pharmacological Treatments for Anxiety Disorders in Older Adults'".

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same journal

Benefit and Uptake: A Mixed Methods Study Exploring Older Adults' Experiences With a Psychoeducational and Exercise Training Maintenance Intervention.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
See all related articles

Vascular cognitive impairment (VCI) encompasses cognitive changes from cerebrovascular disease, distinct from Alzheimer's. Research needs better diagnostic criteria and targeted treatments for subtypes to improve patient outcomes.

Area of Science:

  • Neurology
  • Geriatrics
  • Cognitive Science

Background:

  • Cerebrovascular disease is a significant cause of cognitive impairment and dementia.
  • Existing terminology, like "dementia," doesn't fully capture cognitive disorders linked to vascular pathology.
  • Vascular cognitive impairment (VCI) is proposed as an umbrella term for these conditions.

Purpose of the Study:

  • To review the evidence base for VCI diagnosis, clinical features, pathophysiology, and management.
  • To discuss historical terminology and its impact on research.
  • To recommend future research directions in VCI.

Main Methods:

  • Literature review of existing studies on VCI.
  • Analysis of diagnostic criteria and proposed subtypes of VCI.

Related Experiment Videos

  • Examination of clinical trial data for VCI treatments.

    • Main Results:

    • VCI presents with distinct cognitive profiles, primarily attentional and executive impairments, and often includes depression.
    • Proposed VCI subtypes include cortical, subcortical, strategic infarct, hypoperfusion, hemorrhagic, and mixed (with AD).
    • Current clinical trials for VCI have yielded generally disappointing results, with modest benefits from some agents.

    Conclusions:

    • Refined and validated diagnostic criteria are needed, especially for mixed dementias.
    • Fundamental gaps exist in understanding VCI pathophysiology, prognosis, and effective therapeutics.
    • Further research focusing on specific VCI subtypes and earlier disease stages is crucial.