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Cerebral perfusion MR imaging using FAIR-HASTE in chronic carotid occlusive disease: comparison with dynamic

Kentaro Ida1, Shiro Akaki, Tetsuro Sei

  • 1Department of Radiology, Okayama University Graduate School of Mediicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. idaken7@mtj.biglobe.ne.jp

Acta Medica Okayama
|September 1, 2006
PubMed

Insights

Flow-sensitive alternating inversion recovery using half-Fourier single-shot turbo spin-echo (FAIR-HASTE) effectively detects cerebral hypoperfusion in chronic carotid occlusive disease. This imaging technique aids in evaluating reduced blood flow and its improvement after revascularization.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Chronic carotid occlusive disease can lead to cerebral hypoperfusion, increasing stroke risk.
  • Accurate detection of hypoperfusion is crucial for patient management and treatment decisions.

Purpose of the Study:

  • To evaluate the efficacy of flow-sensitive alternating inversion recovery using half-Fourier single-shot turbo spin-echo (FAIR-HASTE) in detecting cerebral hypoperfusion.
  • To compare FAIR-HASTE findings with dynamic susceptibility contrast-perfusion magnetic resonance imaging (DSC-pMRI) in patients with carotid stenosis.

Main Methods:

  • FAIR-HASTE was performed on 12 patients with carotid stenosis/occlusion and 24 healthy volunteers.
  • 10 patients underwent DSC-pMRI before and after revascularization.
  • Absolute asymmetry indexes (AIs) were calculated and compared between groups and pre/post-revascularization.

Main Results:

  • Patients with carotid stenosis showed significantly higher AIs compared to normal volunteers (p < 0.0001).
  • AIs significantly decreased after revascularization in both FAIR-HASTE and DSC-pMRI (p = 0.0003).
  • FAIR-HASTE and rCBF signal intensity tended to be lower on the affected side before revascularization.

Conclusions:

  • FAIR-HASTE is a useful tool for detecting and evaluating cerebral hypoperfusion in chronic occlusive carotid disease.
  • The technique demonstrates changes in cerebral blood flow related to carotid stenosis and its treatment.

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