Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New concepts in pacemaker syndrome.

D Michael Farmer1, N A Mark Estes, Mark S Link

  • 1Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Indian Pacing and Electrophysiology Journal
|September 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of Long-Term Outcomes in Hypertrophic Cardiomyopathy: The NHLBI HCM Registry.

JAMA·2026
Same author

Resuscitated Cardiac Arrest From Cardiac Sarcoidosis in a Professional Basketball Player: A Slam Dunk Diagnosis?

JACC. Case reports·2026
Same author

Major adverse cardiovascular and bleeding outcomes in paroxysmal vs. non-paroxysmal atrial fibrillation: an individual patient-level data analysis of a large cohort of patients from the COMBINE-AF.

European journal of internal medicine·2026
Same author

Precision Medicine for Electrocardiogram Interpretation: Clinical Relevance, Challenges, and Advances.

Reviews in cardiovascular medicine·2026
Same author

Mitigation of pacing-induced cardiomyopathy with superficial right ventricular midseptal pacing: Failure of stylet-driven leads to duplicate 3830 success.

Heart rhythm O2·2025
Same author

Impact of Timing of Atrial Fibrillation Ablation on AF Recurrence and Clinical Outcomes in Patients With HFpEF and HFrEF.

Journal of cardiovascular electrophysiology·2025
Same journal

Takotsubo cardiomyopathy complicated by persistent complete heart block treated with conduction system pacing: A case report.

Indian pacing and electrophysiology journal·2026
Same journal

Impact of recording technologies on cardiac electrogram morphology: implications for mapping and interpretation.

Indian pacing and electrophysiology journal·2026
Same journal

Meta-analysis of the safety of outpatient Sotalol initiation in clinical practice.

Indian pacing and electrophysiology journal·2026
Same journal

Helix-fixation atrial leadless pacing for rhythm-mediated cardiogenic shock after acute myocardial infarction.

Indian pacing and electrophysiology journal·2026
Same journal

PERMANENT LEFT VENTRICULAR PACING IN A PATIENT WITH POST-METALLIC TRICUSPID VALVE REPLACEMENT COMPLETE HEART BLOCK- A CASE REPORT.

Indian pacing and electrophysiology journal·2026
Same journal

Dual conduction in an atriofascicular pathway.

Indian pacing and electrophysiology journal·2026
See all related articles

Pacemaker syndrome, causing symptoms like shortness of breath, may stem from loss of atrioventricular (A-V) synchrony and left ventricular dyssynchrony due to right ventricular pacing. Optimizing pacemaker settings to favor natural heart rhythms may reduce these adverse effects.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Permanent pacemaker implantation can lead to pacemaker syndrome, characterized by dyspnea, palpitations, malaise, and syncope.
  • Pacemaker syndrome is traditionally attributed to loss of atrioventricular (A-V) synchrony.
  • Emerging evidence suggests left ventricular dyssynchrony from right ventricular pacing may also contribute.

Purpose of the Study:

  • To explore the causes of pacemaker syndrome beyond traditional A-V dyssynchrony.
  • To evaluate the impact of ventricular pacing on cardiac synchrony and patient outcomes.
  • To propose programming strategies for dual-chamber pacemakers to mitigate adverse effects.

Main Methods:

  • Review of previous studies comparing dual-chamber (DDDR) pacing with ventricular-based (VVI) pacing.

Related Experiment Videos

  • Analysis of the role of interventricular (V-V) dyssynchrony in DDDR pacing.
  • Discussion of potential programming modifications to enhance intrinsic A-V conduction.

    • Main Results:

    • Previous studies did not demonstrate significant reductions in mortality or stroke with DDDR pacing versus VVI pacing.
    • The benefits of A-V sequential pacing in DDDR mode may be counteracted by V-V dyssynchrony from high right ventricular pacing percentages.
    • Right ventricular pacing is implicated in left ventricular dyssynchrony.

    Conclusions:

    • Optimizing DDDR pacemaker programming to promote intrinsic A-V conduction and minimize right ventricular pacing is a potential strategy.
    • Such programming adjustments may decrease the incidence of heart failure and pacemaker syndrome.
    • Further studies are ongoing to validate these findings and programming approaches.