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Updated: Jul 20, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
Single-chamber versus dual-chamber implantable cardioverter defibrillators: do we need physiologic pacing in the
Marco Budeus1, Thomas Buck, Heinrich Wieneke
1Department of Cardiology, West-German Heart Centre, University of Duisburg-Essen, Germany. marco.budeus@medizin.uni-essen.de
Insights
Dual-chamber ICD pacing (DDD(R)) significantly improved heart failure symptoms and objective measures compared to single-chamber pacing (VVI(R)). This upgrade reduced ventricular pacing and enhanced patient outcomes, demonstrating DDD(R) superiority.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Patients with implantable cardioverter-defibrillators (ICDs) often receive antiarrhythmic drugs for tachycardias.
- These drugs can lead to AV-block or chronotropic incompetence, increasing ventricular pacing.
Purpose of the Study:
- To evaluate the impact of upgrading from VVI(R) to DDD(R) pacing mode in patients with ICDs.
- To assess changes in subjective and objective heart failure parameters.
Main Methods:
- Retrospective study of 12 patients upgraded from VVI(R) to DDD(R) ICD pacing.
- Data collected at baseline (VVI(R)) and after 6 and 12 months of DDD(R) pacing.
- DDD(R) pacing utilized a long AV-interval and AV hysteresis to minimize ventricular pacing.
Main Results:
- Significant improvements observed in 6-minute walk test, NYHA classification, BNP levels, and left ventricular ejection fraction with DDD(R) pacing.
- Ventricular pacing decreased from 84.2% to 1.1% after 12 months of DDD(R) pacing.
- Enhanced atrial contraction contributed to improved hemodynamic parameters.
Conclusions:
- DDD(R) pacing mode demonstrates superiority over VVI(R) mode in improving subjective and objective parameters in ICD patients.
- Reduced ventricular pacing through DDD(R) pacing is associated with enhanced cardiac function and patient outcomes.
- Upgrading to DDD(R) pacing is beneficial for patients experiencing chronotropic incompetence and progressing heart failure.
Background:
Many patients with ICD receive different antiarrhythmic drugs (e.g. sotalol, amiodarone, beta-blockers) because of ventricular or atrial tachycardias. These drugs can cause AV-block or chronotropic incompetence resulting in a higher percentage of ventricular pacing.
Methods:
We analyzed in a retrospective study the impact of DDD(R) versus VVI(R) mode on subjective (NYHA classification) and objective parameters [brain natriuretic peptide (BNP), 6 minute walk test, echocardiography] in 12 of 120 patients (age 60.2 +/- 11.2 years; 10 males, 2 females) who needed an upgrading of a single to a dual chamber ICD. The ICD had to be upgraded because of chronotropic incompetence in all patients with signs of progressing heart failure. Data were collected in VVI(R)-pacing and after 6 and 12 months in DDD(R)-pacing with a long AV-interval and AV hysteresis to reduce ventricular pacing.
Results:
The 6 minute walk test (392.4 +/- 91.4 vs. 324.6 +/- 93.3 m, P < 0.001), NYHA-classification (1.4 +/- 0.3 vs. 2.6 +/- 0.8, P < 0.0001), BNP (234.1 +/- 73.5 vs. 410.4 +/- 297.0 pg/ml, P < 0.001), left ventricular ejection fraction (49.8 +/- 9.6 vs. 36.5 +/- 10.9 %, P < 0.0001) and A-wave (73.6 +/- 13.7 vs. 41.0 +/- 14.0 cm/sec, P < 0.0001) improved with DDD(R)-pacing after 12 months. The ventricular pacing decreased (84.2 +/- 18.1 vs. 1.1 +/- 1.7 %, P < 0.0001) after 12 months by DDD(R)-pacing with long AV-interval (220.0 +/- 10.4 ms) and AV hysteresis.
Conclusion:
Our data show a superiority of DDD(R) mode versus VVI(R) mode regarding subjective and objective parameters as NYHA-classification, BNP, 6 minute walk test, left ventricular ejection fraction and left ventricular endsystolic volume after 12 months. The improvements seem to depend on the reduction of ventricular pacing with advanced atrial contraction. But only a small number of patients needed the upgradation.
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