Single-chamber versus dual-chamber implantable cardioverter defibrillators: do we need physiologic pacing in the

Marco Budeus1, Thomas Buck, Heinrich Wieneke

  • 1Department of Cardiology, West-German Heart Centre, University of Duisburg-Essen, Germany. marco.budeus@medizin.uni-essen.de

Insights

Dual-chamber ICD pacing (DDD(R)) significantly improved heart failure symptoms and objective measures compared to single-chamber pacing (VVI(R)). This upgrade reduced ventricular pacing and enhanced patient outcomes, demonstrating DDD(R) superiority.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Patients with implantable cardioverter-defibrillators (ICDs) often receive antiarrhythmic drugs for tachycardias.
  • These drugs can lead to AV-block or chronotropic incompetence, increasing ventricular pacing.

Purpose of the Study:

  • To evaluate the impact of upgrading from VVI(R) to DDD(R) pacing mode in patients with ICDs.
  • To assess changes in subjective and objective heart failure parameters.

Main Methods:

  • Retrospective study of 12 patients upgraded from VVI(R) to DDD(R) ICD pacing.
  • Data collected at baseline (VVI(R)) and after 6 and 12 months of DDD(R) pacing.
  • DDD(R) pacing utilized a long AV-interval and AV hysteresis to minimize ventricular pacing.

Main Results:

  • Significant improvements observed in 6-minute walk test, NYHA classification, BNP levels, and left ventricular ejection fraction with DDD(R) pacing.
  • Ventricular pacing decreased from 84.2% to 1.1% after 12 months of DDD(R) pacing.
  • Enhanced atrial contraction contributed to improved hemodynamic parameters.

Conclusions:

  • DDD(R) pacing mode demonstrates superiority over VVI(R) mode in improving subjective and objective parameters in ICD patients.
  • Reduced ventricular pacing through DDD(R) pacing is associated with enhanced cardiac function and patient outcomes.
  • Upgrading to DDD(R) pacing is beneficial for patients experiencing chronotropic incompetence and progressing heart failure.
Abstract

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
Conduction System of the Heart01:19

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...