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Updated: Jul 20, 2026
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
Published on: February 14, 2025
Influence of pretreatment polarographically measured oxygenation levels in spontaneous canine tumors treated with
Carla Rohrer Bley1, Stefanie Ohlerth, Malgorzata Roos
1Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. crohrer@vetclinics.unizh.ch
Background And Purpose:
The level of hypoxia in primary tumors has been described to influence response to treatment. The aim of the present study was to investigate the impact of pretreatment oxygen level measurements in spontaneous canine tumors on treatment outcome.
Materials And Methods:
Data of pretreatment tumor oxygenation status and local tumor response after primary radiation therapy in a group of spontaneously occurring tumors in dogs (n=52) was collected. Radiation therapy was given with curative (14-17x3-3.5 Gy) or palliative intent (3x8 Gy or 4-5x6 Gy). Progression-free interval and overall survival were correlated to polarographically measured tumor oxygenation status.
Results:
In the curatively irradiated group, tumors with median pO2 values
Conclusion:
In curatively irradiated spontaneous canine tumors, tumor hypoxia was found to be a prognostic indicator, independent of tumor histologies and volume.
