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Interaction between warfarin and cranberry juice.

Jonathan L Aston1, Amy E Lodolce, Nancy L Shapiro

  • 1Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

Pharmacotherapy
|September 2, 2006
PubMed
Summary
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Warfarin anticoagulation can be disrupted by cranberry juice, potentially causing dangerous fluctuations. Patients should avoid large volumes of cranberry juice while on warfarin therapy to maintain stable anticoagulation.

Area of Science:

  • Pharmacology
  • Drug Interactions
  • Nutritional Science

Background:

  • Warfarin is a widely prescribed anticoagulant for preventing blood clots.
  • Maintaining a stable international normalized ratio (INR) is crucial for warfarin efficacy and safety.
  • Fluctuations in INR can lead to serious complications such as bleeding or therapeutic failure.

Purpose of the Study:

  • To analyze the potential interaction between warfarin and cranberry juice.
  • To assess the clinical significance of cranberry juice consumption on warfarin therapy.
  • To provide guidance for clinicians regarding this potential drug-food interaction.

Main Methods:

  • Literature review and analysis of existing studies on warfarin and cranberry juice.
  • Examination of reports on international normalized ratio (INR) fluctuations in patients taking warfarin concurrently with cranberry juice.

Related Experiment Videos

  • Evaluation of recommendations from regulatory bodies like the UK's Committee on Safety of Medicines.

    • Main Results:

    • Ingestion of large volumes of cranberry juice has been shown to destabilize warfarin therapy.
    • The interaction can lead to significant international normalized ratio (INR) fluctuations.
    • Small amounts of cranberry juice are not expected to cause clinically relevant interactions.

    Conclusions:

    • Clinicians must be aware of the potential for cranberry juice to interact with warfarin.
    • Patient counseling regarding cranberry juice consumption is essential.
    • Monitoring of international normalized ratio (INR) is recommended for patients on warfarin who consume cranberry juice.