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Updated: Jul 20, 2026
11:10
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Congenital hyperinsulinism. Review of 22 cases]
J Guerrero-Fernández1, I González Casado, L Espinoza Colindres
1Servicio de Endocrinología Pediátrica, Hospital Infantil La Paz, Madrid, España.
Anales De Pediatria (Barcelona, Spain : 2003)
|September 2, 2006
Summary
Congenital hyperinsulinism (CHI) is a genetic disorder causing hypoglycemia in children. Early diagnosis and treatment are crucial to prevent neurological complications.
Area of Science:
- Pediatric Endocrinology
- Genetics
- Metabolic Disorders
Context:
- Congenital hyperinsulinism (CHI) is a leading cause of recurrent hypoglycemia in early childhood.
- CHI involves genetic defects leading to insulin secretion dysregulation.
Purpose:
- To review the clinical presentation, management strategies, and patient outcomes for congenital hyperinsulinism.
- This study retrospectively analyzed patients diagnosed with CHI between 1982 and 2004.
Summary:
- Twenty-two CHI patients were identified with early symptom onset in 80% of cases.
- Surgical intervention, specifically pancreatectomy, was performed in 72% of patients.
- Neurological sequelae, including abnormal neurodevelopment and epilepsy, affected 28% of patients.
Impact:
- Findings align with existing literature on CHI presentation and outcomes.
- Highlights the critical need for prompt diagnosis and intervention in CHI.
- Emphasizes the importance of managing CHI to mitigate long-term neurological deficits.
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