[Acute necrotizing pancreatitis: therapeutic alternatives]
Laureano Fernández-Cruz1, Rubén R Lozano-Salazar, Cristóbal Olvera
1Institut Clínic de Malalties Digestives, Departamento de Cirugía, Hospital Clínic i Provincial de Barcelona, Universidad de Barcelona, Barcelona, España. lfcruz@clinic.ub.es
Abstract:
The management of acute necrotizing pancreatitis has changed significantly over the last few years. Currently, most patients survive the early phases of the disease due to improvements in intensive care unit management. The most important risk factor for morbidity and mortality is infection of the pancreatic necrosis. Ideally, surgery should be delayed until 4 weeks after the onset of symptoms of pancreatitis, as it is at this time that the necrosis is most clearly demarcated. Advances in diagnostic imaging and minimally invasive techniques in surgery and radiology have revolutionized the surgical management of this disease. However, minimally invasive techniques should be limited to critically-ill patients unfit for conventional surgery.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

