Related Experiment Video
Updated: Jul 20, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
Proliferative arrest and activation of apoptosis related genes in Rolly Protein-silenced cells
Aldo Pagano1, Laura Tonachini, Massimiliano Monticone
1Dipartimento di Oncologia Biologia e Genetica, Università di Genova, Italy. aldo.pagano@istge.it
Abstract:
Here we describe a novel small polypeptide expressed in chick embryo and mouse adult tissues referred to as Rolly Protein (Rolp), expressed at the highest levels in tibial cartilage and lung respectively. Investigating its putative role in cartilage differentiation we found that its expression is restricted to proliferative stages consistently with a decreased proliferation rate observed in Rolp-silenced cells. Additional functional studies demonstrate that inhibition of Rolp expression causes a transcription modulation of genes involved in apoptosis. The results here provided strongly suggest an active role of Rolp in the control of cell proliferation and apoptosis.
Related Concept Videos
Negative Regulator Molecules
Abnormal Proliferation
DNA Damage Can Stall the Cell Cycle
DNA Damage can Stall the Cell Cycle
PI3K/mTOR/AKT Signaling Pathway
The Intrinsic Apoptotic Pathway

