Autoimmune diseases, asthma and risk of haematological malignancies: a nationwide case-control study in Sweden
Karin C Söderberg1, Fredrik Jonsson, Ola Winqvist
1Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171-77, Stockholm, Sweden. karin.soderberg@ki.se <karin.soderberg@ki.se>
Abstract:
To investigate potential associations between several autoimmune diseases and haematological malignancies, we studied 39,908 cases of leukaemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma that occurred during 1987-1999 in Sweden, and 149,344 controls. Hospital discharge diagnoses of psoriasis, Sjögren's syndrome, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura, pernicious anaemia, multiple sclerosis, rheumatic fever or asthma from 1969 to 1999 were retrieved from the Swedish Hospital Discharge Registry. Psoriasis was positively associated with leukaemia, excluding chronic lymphocytic leukaemia, (odds ratio [OR]=1.6, 95% confidence interval [CI] 1.1-2.3) and non-Hodgkin's lymphoma (OR=1.6, 95% CI 1.3-2.1). Sjögren's syndrome increased the risks of all haematological malignancies combined (OR=4.0, 95% CI 2.3-7.0), and of non-Hodgkin's lymphoma (OR=6.4, 95% CI 3.5-12). These findings, together with increased risks of several haematological malignancies in autoimmune haemolytic anaemia and idiopathic thrombocytopenic purpura but not in asthma, suggest chronic autoimmunity and immune stimulation as mechanisms contributing to the development of haematological malignancies.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Asthma I: Introduction
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
