Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD4+ and CD56+ acute monoblastic leukemia.

T Tauchi1, K Ohyashiki, J H Ohyashiki

  • 1First Department of Internal Medicine, Tokyo Medical College, Japan.

American Journal of Hematology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term remission of acquired von Willebrand syndrome associated with multiple myeloma using bortezomib and dexamethasone therapy.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4.

Leukemia & lymphoma·2016
Same author

Human herpesvirus 6 reactivation on the 30th day after allogeneic hematopoietic stem cell transplantation can predict grade 2-4 acute graft-versus-host disease.

Transplant infectious disease : an official journal of the Transplantation Society·2014
Same author

A novel reduced-intensity umbilical cord blood transplantation using a recombinant G-CSF combined with high-dose Ara-C for active myeloid malignancies.

Bone marrow transplantation·2014
Same author

Monosomal karyotype in MDS: explaining the poor prognosis?

Leukemia·2013
Same author

Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders.

Blood cancer journal·2012

This study details a rare acute monoblastic leukemia case with unique CD4, CD56, and CD36 antigen expression. The findings suggest a monocyte origin for these leukemia cells, lacking lymphoid gene rearrangements.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Acute monoblastic leukemia (AML-M5) is a subtype of acute myeloid leukemia characterized by a predominance of monoblasts.
  • Leukemia cell immunophenotyping is crucial for diagnosis, classification, and understanding lineage commitment.
  • CD56 is typically associated with Natural Killer (NK) cells, and its presence on myeloid leukemia cells is uncommon.

Observation:

  • A patient presented with acute monoblastic leukemia.
  • Leukemia cells expressed CD4 (T4), CD56 (NKH-1), and CD36 (OKM5) antigens.
  • These leukemia cells lacked NK cell activity and antibody-dependent cellular cytotoxicity (ADCC).

Findings:

  • Immunoglobulin heavy (IgH) chain and T cell receptor (TCR)-beta chain gene analyses revealed no rearrangements.

Related Experiment Videos

  • The absence of IgH and TCR rearrangements indicated a non-lymphoid origin of the leukemia cells.
  • The co-expression of CD56 on monoblastic leukemia cells without lymphoid markers is a key finding.

    • Implications:

    • This case suggests that leukemia cells can originate from monocytes expressing NK-associated antigens.
    • The findings expand the understanding of myeloid leukemia cell differentiation and antigen expression.
    • Further research into the origins of leukemia with unusual immunophenotypes is warranted.