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Updated: Jul 20, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis
Enos Tangke Arung1, Kuniyoshi Shimizu, Ryuichiro Kondo
1Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Abstract:
In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.
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