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Zone I retinopathy of prematurity: clinical characteristics and treatment outcomes

Andres Kychenthal1, Paola Dorta, Ximena Katz

  • 1Hospital de Niños Roberto del Río, Santiago, Chile. akychenthal@entelchile.net

Retina (Philadelphia, Pa.)
|September 2, 2006
PubMed

Insights

Laser photocoagulation shows limited success in posterior zone I retinopathy of prematurity (ROP) in infants. However, surgery effectively reattaches retinas in many cases of zone I ROP-related retinal detachment.

Area of Science:

  • Ophthalmology
  • Neonatal care
  • Retinal diseases

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Zone I ROP, the earliest and most peripheral form, presents unique clinical challenges.
  • Understanding treatment outcomes for zone I ROP is crucial for optimizing infant eye care.

Purpose of the Study:

  • To investigate the clinical characteristics of zone I ROP.
  • To evaluate treatment outcomes of laser and surgical interventions for zone I ROP.
  • To compare the efficacy of different treatment modalities in infants with zone I ROP.

Main Methods:

  • Retrospective study of preterm infants (<1,500g) with zone I ROP.
  • Indirect diode laser photocoagulation for 57 eyes; surgical treatment for 27 eyes with retinal detachment.
  • Classification into anterior and posterior zone I subgroups; structural outcomes assessed 3 months post-surgery.

Main Results:

  • Atypical morphologic features were noted in zone I ROP.
  • Favorable outcomes after laser photocoagulation were 64.6% for anterior zone I ROP vs. 0% for posterior zone I ROP (P < 0.001).
  • Surgical success rates were 74% for stage 4 and 13% for stage 5 retinal detachment.

Conclusions:

  • Zone I ROP can exhibit atypical clinical presentations.
  • Posterior zone I ROP has a poorer prognosis with laser photocoagulation.
  • Surgical intervention is effective for significant retinal reattachment in zone I ROP-related detachments.
Abstract

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