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[Neurocognitive and psychosocial development in SGA and the indication for growth hormone therapy]

M Noeker1

  • 1Zentrum für Kinderheilkunde der Universität Bonn. m.noeker@uni-bonn.de

Klinische Padiatrie
|September 2, 2006
PubMed

Insights

Growth hormone therapy (GHT) for small for gestational age (SGA) may improve neurocognitive and behavioral outcomes. Prognosis varies, with short stature-related issues responding best to GHT, while global issues may need psychological interventions.

Area of Science:

  • Pediatric Endocrinology
  • Developmental Psychology
  • Neuroscience

Background:

  • Small for gestational age (SGA) is associated with potential neurocognitive, behavioral, and educational impairments.
  • Growth hormone therapy (GHT) is now indicated for SGA, raising expectations beyond growth improvement.
  • Predicting individual developmental risks and GHT response in SGA remains challenging.

Purpose of the Study:

  • To review neurocognitive and psychosocial outcomes in SGA.
  • To present a framework for understanding developmental risks in SGA.
  • To guide clinical differentiation between short stature-related and independent behavioral disorders.

Main Methods:

  • Review of clinical and population-based studies on SGA neurocognitive and psychosocial outcomes.
  • Delineation of an integrative framework for developmental risk in SGA.
  • Analysis of factors influencing response to GHT.

Main Results:

  • SGA is linked to diverse developmental risks, influenced by genetic, placental, and maternal factors.
  • Short stature-related maladjustment responds best to GHT for psychosocial outcomes.
  • Global developmental disturbances independent of short stature may require child psychology interventions.

Conclusions:

  • Clinical differentiation is crucial for tailoring interventions in SGA.
  • GHT effectiveness for psychosocial outcomes is highest in cases with specific short stature-related maladjustment.
  • Child psychology interventions are vital for SGA individuals with global, short stature-independent disturbances.

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