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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Atherosclerosis: immune and inflammatory aspects
1Vascular Biology Institute, Winthrop University Hospital, 222 Station Plaza, North, Suite 511-A, Mineola, NY 11501, USA. AReiss@Winthrop.org
Abstract:
This review article discusses the historical origin of our continuously evolving model of the etiology of atherosclerotic cardiovascular disease. The basic molecular biologic concepts underlying the development of coronary artery disease and the dynamic connection between the immune system and arterial integrity are explored. Emphasis is placed on the role of inflammation as a driving force in the process of atherosclerosis and vascular endothelium as a modulating factor in the pathogenesis of coronary artery disease.
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